Pharmacognostic standardization and hypoglycemic evaluations of novel polyherbal formulations. Lanjhiyana S, Garabadu D, Ahirwar D, Rana CA, Ahirwar B, Lanjhiyana SK. Hypoglycemic and antioxidant effects of a polyherbal formulation in alloxan induced diabetic rats. Antidiabetic activity of a polyherbal formulation(Karnim Plus). Hypoglycemic and antilipidperoxidative effects of a polyherbal formulation, Diakyur, in experimental animal models. Antihyperglycemic and antioxidative effects of a herbal formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a mouse model of type 2 diabetes mellitus. Eur Rev Med Pharmacol Sci, 2013,17(3):356-369Ĭhan JY, Lam FC, Leung PC, Che CT, Fung KP. DIA-2, a polyherbal formulation ameliorates hyperglycemia and protein-oxidation without increasing the body weight in type II diabetic rats. Kesavanarayanan KS, Sathiya S, Kalaivani P, Ranju V, Sunil AG, Saravana Babu C, Kavimani S, Prathiba D. In vitro toxicity and antidiabetic activity of a newly developed polyherbal formulation(MAC-ST/001) in streptozotocin-induced diabetic Wistar rats. Yadav D, Chaudhary AA, Garg V, Anwar MF, Rahman MM, Jamil SS, Khan HA, Asif M. Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system. Pharmacological evaluation of “Glyoherb”: a polyherbal formulation on streptozotocin-induced diabetic rats. Preventive effect of diabegon, a polyherbal preparation, during progression of diabetes induced by high-fructose feeding in rats. Antidiabetic activity of a polyherbal formulation(DRF/AY/5001). Mandlik RV, Desai SK, Naik SR, Sharma G, Kohli RK. BMC Complement Altern Med, 2005,5:14Ĭhang MS, Oh MS, Kim do R, Jung KJ, Park S, Choi SB, Ko BS, Park SK.Effects of okchun-san, a herbal formulation, on blood glucose levels and body weight in a model of type 2 diabetes. Antihyperlipidemic and antiperoxidative effect of Diasulin, a polyherbal formulation in alloxan induced hyperglycemic rats. Comp Biochem Physiol C Toxicol Pharmacol, 2002,131(1):19-25 Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus. 2004 134(12 Suppl):3479S-3485S.īabu PS, Stanely Mainzen Prince P.Antihyperglycaemic and antioxidant effect of hyponidd, an ayurvedic herbomineral formulation in streptozotocin-induced diabetic rats. Potential synergy of phytochemicals in cancer prevention: mechanism of action. Natural ingredients for diabetes which are approved by Korean FDA. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Shafiee-Nick R, Ghorbani A, Vafaee F, Rakhshandeh H. Effects of fenugreek seeds on adipogenesis and lipolysis in normal and diabetic rat. Ghorbani A, Hadjzadeh MAR, Rajaei Z, Zendehbad SB. Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats. Ghorbani A, Shafiee-Nick R, Rakhshandeh H, Borji A. Best herbs for managing diabetes: a review of clinical studies. Oral hypoglycemic drugs: pathophysiological basis of their mechanism of action. Lorenzati B, Zucco C, Miglietta S, Lamberti F, Bruno G. Epidemiology of diabetes and diabetes-related complications. Key words: Diabetes mellitus, Hypoglycemic agents, Plants, Medicinal, Reviewĭeshpande AD, Harris-Hayes M, Schootman M. Also, the possible mechanisms responsible for hypoglycemic action of polyherbal formulations are discussed. The percent decrease in blood glucose, lipids and other biochemical parameters achieved by each product in diabetic animals and patients is reported. This paper presents what is known about the efficacy of these polyherbal formulations and compare their antidiabetic effects with those of current oral hypoglycemic drugs as reference. To describe the current state of research on polyherbal compounds in the treatment of diabetes, an extensive review of literature was undertaken on several major databases. Several polyherbal formulations have been studied as therapeutic agents in diabetes management. It is believed that herbal compounds containing multiple plant products have synergistic antidiabetic effects and could enhance the desired actions. Although numerous individual herbs have been experimentally or clinically reported to possess antidiabetic effects, considerably less research has been conducted on polyherbal compounds. There is currently an active search for antidiabetic drugs with greater effectiveness with fewer and less adverse side effects. Diabetes is a leading cause of morbidity and mortality in the world.
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